《实验动物与的比较医学杂志》论文模版.doc

《实验动物与比较医学杂志》论文模版 李颖1,苗海卫1,黄成磊,乔伟伟2, 罗心平1,梁旺3，李 剑1, 朱 军1, 沈 伟1,金 波1,施海明1 (复旦大学1. 附属华山医院, 上海 200040；2. 实验动物科学部, 上海 200032；3 教育部分子医学重点实验室，上海 200032) ①姓名之间加逗号，单位序号标在右上角；②单位前面有序号(如：1.)；③单位后面有逗号城市名及邮编 [摘要] （加方括号，内容按结构式四要素格式书写）目的 在新西兰兔股动脉粥样硬化血管狭窄模型建立中运用白介素-1β，探讨其可行性并与既往造模方法进行比较。方法 新西兰兔通过局部股动脉包裹白介素-1β，后行高脂饲料饲养，建立动脉粥样硬化血管狭窄模型。在X线透视下经颈动脉行股动脉球囊损伤，评判造模前后的股动脉血流分级(TIMI)评分、管腔内径，以及血管内膜厚度和泡沫细胞阳性面积的变化。结果 与高脂对照模型组比较，该模型组的股动脉管腔内径显著狭窄(P0.001)。同时，血管内膜泡沫细胞阳性面积率显著增多(P0.05)。结论 运用白介素-1β建立股动脉粥样硬化血管狭窄模型具有可行性，操作简便，可控程度高、易重复。与既往模型相比, 更有助于进一步阐明炎症介导的动脉粥样硬化斑块的机制。 [关键词] （加方括号，有3～5个关键词，之间加分号隔开）动脉粥样硬化； 白介素-1β； 新西兰兔 [中图分类号]Q95-33查阅中国图书分类法 [文献标识码] A [文章编号] 1674-5817(2011)01-0000 Establishment of Angiostenosis Model on New Zealand Rabbit on Basis of Interleukin-1βLI Ying1, MIAO Hai-wei1, HUANG Cheng-lei1, QIAO Wei-wei2, LUO Xin-ping1,LIANG Wang3 ,LI Jian1, ZHU Jun1, SHEN Wei1, JIＮ Bo1, SHI Hai-ming1 (1.Huashan Hospital ,Fudan University, 200040,China 2.Department of Laboratory Animal sciencee,Fudan University,200032,China 3.Key laboratory of Molecular Medicine ,Ministry of Education ,Fudan University,200032,China) 格式同中文，但姓全大写，名的第一个字母大写；按第三人称、被动态写作！！ [Abstract] Objective To establish an angiostenosis model on New Zealand rabbit on the basis of Interleukin-1βand evaluate the model compared with traditional animal model.Methods The femoral artery were wrapped with Interleukin-1βbeads on New Zealand rabbits and than the animals were fed with high cholesterol diet to establish the angiostenosis model, endothelium thickness, foam cell area were determined, and TIMI was monitored. Result Compared with the contrast group, angiostenosis model group presents significant stenosis of the femoral artey, and thickening of the endothelium and increasing of the positive area of foam cells. Conclusion The angiostenosis model, which is accurately controlled and easily repeated, could be used to evaluate the mechanism of the plaque on inflammation correlated to the progress of atherosclerosis. [Key words] Athe