胺碘酮联合缬沙坦对非瓣膜性持续性心房颤动患者窦性心律的维持作用.docVIP

胺碘酮联合缬沙坦对非瓣膜性持续性心房颤动患者窦性心律的维持作用 　　作者：吴彩娟， 王燕萍， 吴 杰 作者单位：(海门市人民医院心内科，江苏 海门226100) 　　【摘要】 目的： 评价胺碘酮联合缬沙坦对非瓣膜性持续性心房颤动(房颤)患者维持窦性心律的疗效。方法： 将65例非瓣膜性持续性心房颤动患者随机分为对照组(32例)，试验组(33例)。对照组予胺碘酮，试验组予胺碘酮+缬沙坦。入选患者转复为窦性心律后即为试验起始时间，试验终点为转复后12个月。终点事件：症状或无症状房颤首次复发。比较两组治疗后的窦性心律维持率及治疗前，治疗后6、12个月左心房内径。 结果： 有63例完成试验，其中对照组31例，试验组32例，试验组窦性心律维持率显著高于对照组(78.1%与51.6%，P0.05)。治疗12个月后，试验组左心房内径(LAD)显著小于对照组(P0.05)。 结论： 胺碘酮联合缬沙坦对非瓣膜性持续性房颤复律后维持窦性心律的疗效优于单用胺碘酮，并能抑制左心房的扩大。 　　【关键词】 心房颤动; 缬沙坦; 胺碘酮; 非瓣膜性 　　Comparison of amiodarone plus valsartan regimen versus amiodarone 　　alone on maintaining sinus rhythm in nonvalvular patients 　　with persistent atrial fibrillation 　　WU Caijuan, WANG Yanpin , WU Jie 　　(Department of Cardiology, Haimen Peoples Hospital , Haimen Jiangsu 226100,China) 　　[Abstract] Objective: To evaluate the efficacy of amiodarone in combination with valsartan on maintenance of sinus rhythm in patients with nonvalvular persistent atrial fibrillation(AF).Methods： Patients with nonvalvular persistent atrial fibrillation were randomly divided into amiodarone group(A,n=32) and amiodarone plus valsartan group (AV,n=33).The selected patients transformed into sinus rhyhm was the starting time. Patients were followed up for 12 months after sinus rhythm recovery. The primary end points were first recurrence of symptomatic and asymptomatic AF. Compare sinus rhythm maintenance of the 2 groups and the left atrial diameter(LAD)at before and after 6 and 12month of treatment. Results： Sixtythree cases have finished the experiment, including amiodarone group 31cases and amiodarone plus valsartan group 32 cases.The sinus ryhthm maintenance of group AV was significantly higher than group A(78.1% vs 51.6%,P0.05). Twelve months post therapy,the left atrial diameter(LAD) of group AV was significantly smaller than group A(P0.05) . Conclusions： Combined amiodarone and valsartan use was superior to amiodarone alone for maintaining sinus rhythm in patients with nonvalvular persiste