apoe对小鼠生殖的影响.pdfVIP

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apoe对小鼠生殖的影响.pdf

AUTHOR COPY ONLY REPRODUCTION RESEARCH Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility 1, 2 1 1 Ting Zhang*, Pengyuan Dai *, Dong Cheng , Liang Zhang , Zijiang Chen, Xiaoqian Meng , 1 1 1 1 1 Fumiao Zhang , Xiaoying Han , Jianwei Liu , Jie Pan , Guiwen Yang and Cong Zhang Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China, 1Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, 88 East Wenhua Road, Ji’nan, Shandong 250014, China and 2Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Ji’nan, Shandong 250014, China Correspondence should be addressed to C Zhang; Email: zhangxinyunlife@163.com *(T Zhang and P Dai contributed equally to this work) Abstract The Apolipoprotein (Apo) family is implicated in lipid metabolism. There are five types of Apo: Apoa, Apob, Apoc, Apod, and Apoe. Apoe has been demonstrated to play a central role in lipoprotein metabolism and to be essential for efficient receptor-mediated plasma clearance of chylomicron remnants and VLDL remnant particles by the liver. Apoe-deficient (Apoe K/ K ) mice develop atherosclerotic plaques spontaneously, followed by obesity. In this study, we investigated whether lipid deposition caused by Apoe knockout affects reproduction in female mice. The results demonstrated that Apoe K/ K mice were severely hypercholesterolemic, with their cholesterol metabolism dis

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