NET_1_Ki67和CD34在胃癌组织中的表达及其临床病理意义.pdfVIP

·2 16 · 肿瘤防治研究 2009 年第 36 卷第 3 期 DO I :10 . 397 1/ j . i ssn .. 2009 . 03 . 0 14 N E T1 、Ki67 和 CD34 在胃癌组织中的表达 及其临床病理意义 1 1 1 1 2 王桂兰 ,陈　莉 ,李杏玉 ,王 　酉 , 钱 　铮 Overexpression and Cl inicopathological Signif icance of NET1 , Ki67 and CD34 in Gastric Carcinoma WAN G Guilan 1 , C H EN Li1 , L I Xingyu1 , WAN G You 1 , Q IAN Zheng 2 1. D ep a rt ment of P at holog ical A natomy , N antong Uni ve rs i ty M e d ical S chool , N antong 22600 1 , Chi na; 2 . D ep a rtment of P at hology , H ai men F i rs t Peop le’s H osp i t al Corresp on d i ng A ut hor : C H E N L i , Em ai l :bl1 @ nt u . e d u. cn Abstract :Objective 　 To investigat e t he overexp ression of N E T1 、Ki67 and CD34 and clinicop at hological significance in ga st ric carcinoma . Methods 　The overexp ression of N E T1 、Ki67 and CD34 was det ect ed in 86 ca ses of ga st ric carcinoma p araffinembeded section s by immunohi stochemical met hod . Immunohi sto chemical t rimarker s double st aining met ho d wa s u sed to det ect all po sitive ca ses wit h t he t hree marker s and show t he adj acent relation ship and accomp anying condition s between N E T1 、Ki67 and CD34 on t he one slide . All cases were followed up over 60 mont h s. Results 　The overexp ression rat es of N E T1 , Ki67 and CD34 in ga st ric carcinoma were 56 . 98 % 、74 . 42 % and 62 . 79 % ,resp ectively . There wa s significant po sitive correlation between t hese t hree marker s ( P 0 . 05) . The overexp ression rat e of t hese marker s were remarkably po sitive correlat ed wit h t umor clinical st ages ( P 0 . 05) and negatively correlat ed wit h t umor survival rat e ( P 0 . 05) and met a st a si s ( P 0 . 05) . The survival rat e wit hin 3 and 5 year s were d