低剂量氟尿嘧啶持续输注联合奥沙利铂治疗老年晚期胃肠道恶性肿瘤.docVIP

低剂量氟尿嘧啶持续输注联合奥沙利铂治疗老年晚期胃肠道恶性肿瘤 作者：樊卫飞,王峻,杨民,刘福银 作者单位：江苏省老年医学研究所，江苏 南京 210024 【摘要】 　　［目的］ 观察低剂量氟尿嘧啶(5-Fu)持续输注联合奥沙利铂(L-OHP)方案治疗老年性晚期胃肠道恶性肿瘤的近期疗效及毒副反应等。［方法］ 32例晚期胃肠道恶性肿瘤患者给予 5-Fu 225mg/(m2·d）微量泵持续静脉滴注3周，L-OHP 60mg/m2 d1、8、15，静脉滴注，28d为1个周期，2个周期后评定疗效。［结果］ CR1例，PR14例，NC13例，PD4例，32例病例的总有效率为46.88%(15/32), 其中转移性肝癌患者有效率为64.71%（11/17）。化疗后ECOG评分比化疗前有显著性改善(P0.05)。化疗后毒副反应病人均能耐受。［结论］ 低剂量氟尿嘧啶持续静脉输注联合奥沙利铂方案治疗老年性晚期胃肠道恶性肿瘤是一个有效、低毒，且能显著改善生活质量的化疗方案。 【关键词】 药物疗法　胃肠肿瘤　奥沙利铂 　　Combined Continuous Infusion Fluorouracil with Low-dose and Oxaliplatin in Treatment for Senile Advanced Gastrointestinal Cancer FAN Wei-fei, WANG Jun, YANG Min, et al. (Jiangsu Provincial Geriatrics Research Institute, Nanjing 210024, China) Abstract: ［Purpose］ To evaluate the short?鄄term efficacy and toxicities of the continuous central venous infusion (c.c.v.i) Fluorouracil with low?鄄dose and Oxaliplatin in treatment for senile advanced gastrointestinal cancer. ［Methods］ 5?鄄Fu 225mg/m2·d c.c.v.i for 3 weeks, and Oxaliplatin 60mg/m2 intravenous drip at d1、8、15 were administered in 32 patients with advanced gastrointestinal carcinoma. The regimen was repeated every 28 days. The assessment was carried out after two cycles.［Results］ One patient achieved complete response;14, partial responses; 13, no change; and 4, progressive disease. The overall response rate was 46.88%(15/32). The response rate was 64.71% (11/17) in patient with liver metastasis. The score of ECOG was significantly improved than that before chemotherapy(P0.05). The toxicities of chemotherapy were well tolerated. ［Conclusions］ Combined chemotherapy of continuous infusion 5?鄄Fu with low?鄄dose and Oxaliplatin is an effective, less toxicity regimen which can and improve the quality of life quality in senile advanced gastrointestinal cancer. Key words: drug therapy; gastrointestinal neoplasms; oxaliplatin 近年来，氟尿嘧啶(5?鄄Fu)联合醛氢叶酸钙(CF)、顺铂(DDP)方案，已较多地应用于晚期胃肠道恶性肿瘤的治疗，并取得了较好的客观疗效。但由于顺铂其严重的肾毒性