口腔鳞癌中MMP9的表达与巨噬细胞测定的意义.pdfVIP

2007年第34卷第16期 中国肿瘤临床 90l ·论著· 口腔鳞癌中MMP一9的表达与巨噬细胞测定的意义：l= 摘要 目的：探讨基质金属蛋白酶9(Matrixmctalloproteinase9，MMP一9)的表达和巨噬细胞的浸润在口腔鳞癌 倒口腔鳞癌和10例口腔正常组织的表达情况。结果：MMP一9的表达和巨噬细胞计数在口腔鳞癌中均显著高于正常 其机籼可能与巨噬细胞作用于肿瘤知胞井游助上调肿瘤细胞中ⅥMP-9的表达有关。 关键词 口腔鳞癌 MMP一9巨噬细胞 免疫组化 Studiesonthe ofMMP-9andInfiltrationof Expression inOral CellCarcinoma MacrophageSquamous Ma etal Dai]aimingSongYufengHong and Department0，Oral MtrxillofacialSurgery,theAffiliatedhospitalofGuiycatg Medical Univers吣，Guiyang Abstract the and betweenmatrix Objective：To significance investigate relationship metallopm· teinase9 mMP一91andinfihrationof inthe andmetastasisinoral macmphageprocess硝invasion of eellcarcinoma MMP一9andCD68weredetectedin42 squamous foscc)．Methods：Theexpressions casesofOSCCand10casesofnormaltissuesbyimmunohistochemicalSABCmethod．CD68wasused todetect levelofMMP一9 andtheratioof macrophagesspecifically．Results：Theexpression inOSCC both thanthatinnormal higher mae,哪agessampleswere．significantly of andthe of werecorrelatedwith metasta-- levelMMP-9 countingmacrophages lymph——node expression sisandTNM showed statistic