活性碳吸附丝裂霉素C腹腔化疗预防进展期胃癌术后复发_梁寒.pdfVIP

·274 · 2003 4 41 4 　Chin J Surg, April 2003, Vol.41,No.4 ·· C 梁寒　王仆　王晓娜　刘宁　岳欣　王殿昌　王家仓　郝希山 　　【】　　C(MMC) 。 　　, 124 2 , MMC 50 mg, 3 。3 。。 　　3、5 70.16%,44.51%27.09%, 14.45%, P0.01。 3、5 43.07% 30.06%。 　　MMC 。 , 。 【】　;　, ;　;　 Prospective randomized trial of prophylaxis of postoperative peritoneal carcinomatosis of advanced gastric cancer:intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles LIANGHan, WANG Pu, WANG Xiao-na, LIU Ning, YUE Xin, WANG Dian-chang, WANG Jia-cang, HAO Xi-shan. Department of Gastrointestinal Oncological urgery, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China 【Abstract】　Objective　To evaluate the beneficial effect of intraperitoneally applied mitomy cin bound to actived carbon particle (MMC-CH)in the prevention and treatment of intraabdominal recurrence after curative urgery for ga tric cancer.　Methods　One hunderd and twenty-four patient with radically re ected ga tric cancer infiltrating the ero al urface were randomly divided into group receiving 50 mg mitomycin bound to a olution of 375 mg carbon ad orbent intraperitoneally before clo ure of the abdominal wound (n=62)and a control group (n =62).The patient with MMC-CH and the control group were received y temic chemotherapy 3 month or 3 week after operation re pectively.The po toperative recurrence-free urvival wa evaluated to analyze the benefit of thi treatment.　Results 　After ob ervation for 8 month (range, 2-65).The 3-, 5-year po toperative recurrence-free urvival rate were ignificantly higher in the MMC-CH group (70.16%, 44.51%)than in the control group(27.09%, 14.45%), P0.01.　Conclusion 　Adjuvant intraperitoneal chemotherapy of ga tric cancer by mitomycin bound to actived carbon particle i effected by an increa ed po toperative recurrence-free urvival rate. 【Key words】　Stomac