返魂草提取物对胃溃疡大鼠胃黏膜炎症反应的调节作用_林莉.pdfVIP

第 28卷 第 6期 Vol. 28 No. 6 2 0 1 0年 6月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Jun. 2 0 1 0 林 莉, 杜惠莲,李 琦 (, 110034) : 目的:探讨返魂草提取物对胃溃疡大鼠胃黏膜炎 反应的调节作用方法: 采用冰醋酸注射法制备 大鼠胃溃疡模型, 随机分为模型组雷尼替 丁组(西药组)返魂草低剂量组(低剂量组)返魂草中剂量组( 中剂量 组)和返魂草高剂量组(高剂量组), 设立正常对照组(空白组) 在光镜下观察大鼠溃疡炎 细胞密度, 应用 EL- LIS 法检测血清及胃黏膜 EGF及TNF- A含量结果 返魂草提取物各剂量组均能使再生黏膜炎 细胞密度减 少,与模型组比较有非常显著性差异( P 0. 01), 返魂草中剂量组及高剂量组疗效优于西药组( P 0. 05或P 0. 01)模型组胃黏膜TNF- A 水平较空白对照组明显增加( P 0. 01), 血清TNF- A水平也有 一定程度的上 升( P 0. 05), 返魂草提取物治疗组胃黏膜 TNF- A 水平明显低于模型组 ( P 0. 01) 治疗组血清及胃黏膜 EGF含量较模型组及空白组升高( P 0. 05或P 0. 01) 结论: 返魂草提取物能减轻炎 细胞的浸润, 抑制炎 性细胞因子的释放, 从而促进胃溃疡的愈合,提高胃溃疡愈合质量 :返魂草;胃溃疡; 炎 反应 : R285. 5 : : 1673- 7717( 2010) 06- 1298- 03 The Regual tion Effect of Senecio Canna ifolius Less Extract on Mucosal Inflammation of RatGastric Ulcer Healing LIN Li, DU Hu-i lian, LIQ i ( ffiliated Nursing School of ShenyangM edicalCollege, Shenyang 110034, Liaoning, China) A strac:t O bj ect iv e: To study the effect ofExtract Isolated from Senecio CannabifoliusLess on inflammatory reaction in rat gastricmucosa of ulcer healing. M ethods: The model of gastric ulcer was constructed by injection of acetic acid. The ratswere random ly divided intoM odel group, Ranitidine group, group of low dose of Senecio cannabifolius Less ex- tract, group ofmedium dose ofSenecio cannabifolius Less extract, group ofhigh dose ofSenecio cannabifoliusLess extract and Normal controlgroup. The inflammatory celldensitywere observe