抗生素治疗大鼠急性胰腺炎后肠道真菌的变化与易位的关系 Relationship between multiplication and translocation of intestinal fungi in rats with acute pancreatitis after antibiotic treatment.pdfVIP

® 2009 9 18 ; 17(26): 2714-2717 世界华人消化杂志 年 月 日 wcjd@ ISSN 1009-3079 CN 14-1260/R 研究快报 RAPID COMMUNICATION 抗生素治疗大鼠急性胰腺炎后肠道真菌的变化与易位的 关系 石承先, 陈 喜 ■ 背景资料 石承先, 陈喜, 贵州省人民医院肝胆胰外科 贵州省贵阳市 ment group than in the control group (P 0.05). 重症急性胰腺炎 550002 On day 9, the detection rates of fungi in the mes- (SAP)并发真菌感 通讯作者: 石承先, 主任医师, 550002, 贵州省贵阳市中山东路, 染占全部SAP感染 贵州省人民医院肝胆胰外科. chengxianl@ entery, lungs and pancrease were significantly 患者的40%-70%, 收稿日期: 2009-06-15 修回日期: 2009-09-07 higher in the treatment group than in the control 接受日期: 2009-09-07 在线出版日期: 2009-09-18 病 死 率 高 达 group (all P 0.05). The multiplication of intesti- 20%-53.1%. 导致 nal fungi was positively correlated with intestinal SAP患者中后期真 菌感染的因素是 Relationship between fungal translocation and serum (1, 3)-β-D-glucan 多方面的, 多数学 multiplication and level (r = 0.8972 and 0.7970, respectively). 者认为重要的原 因可能与广谱抗 translocation of intestinal fungi CONCLUSION: The multiplication and translo- 生素的长时间使 in rats with acute pancreatitis cation of intestinal fungi are significant on days 用有关. 在真菌感 染的防治方面, 大 after antibiotic treatment 6 to 9 in rats with AP after antibiotic treatment. 多数学者主张在 Prophylactic antifungal therapy is reasonable 临床明确真菌感 Che