《A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development》.pdfVIP

NEURAL REGENERATION RESEARCH Volume 8, Issue 1, January 2013 doi:10.3969/j.issn.1673-5374.2013.01.003 [; ] Ma ZX, Li QY, Zhang ZY, Zheng YF. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013;8(1):24-30. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development*******★ Zhixing Ma, Qingyu Li, Zhengyu Zhang, Yufang Zheng School of Life Sciences, Fudan University, Shanghai 200433, China Abstract The multiple-layer structure of the cerebral cortex is important for its functions. Such a structure is Zhixing Ma★, Master. generated based on the proliferation and differentiation of neural stem/progenitor cells. Notch Corresponding author: functions as a molecular switch for neural stem/progenitor cell fate during cortex development but Yufang Zheng, Ph.D., the mechanism remains unclear. Biochemical and cellular studies showed that Notch receptor Associate professor, School of Life Sciences, Fudan activation induces several proteases to release the Notch intracellular domain (NICD). A Disintegrin University, Shanghai 200433, and Metalloprotease 10 (ADAM10) might be a physiological rate-limiting S2 enzyme for Notch China, zhengyf@. activation. Nestin-driven conditional ADAM10 knockout in mouse cortex showed that ADAM10 is critical for maintenance of the neural stem cell population during early embryonic cortex Received: 2012-07-16 development. Howev