《Assistant radiotherapeutic effect of Jiaqi Mixture on tumorbearing mice》.pdfVIP

Chinese-German Journal of Clinical Oncology June 2012, Vol. 11, No. 6, P353–P355 DOI 10.1007/s10330-012-0908-x Assistant radiotherapeutic effect of Jiaqi Mixture on tumor-bearing mice Shichao Wei, Chenyu Zhang, Guang Du, Baoxia Ma Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Received: 26 September 2011 / Revised: 20 December 2011 / Accepted: 25 January 2012 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012 Abstract Objective: The aim was to study the assistant radiotherapeutic effect of Jiaqi Mixture (JQM) on Ehrlich’s ascites carcinoma (EAC) mice. Methods: The EAC-cancer model was made up with Kunming mice. The tumor-bearing mice were treated with whole body exposure (8 Gy) and intragastric administration of JQM, and the changes of tumor weight, the total number of white blood cells (WBC) and immune system were observed. Results: The average tumor weight, WBC, spleen co- efficient, the stimulation index (SI) of Con A and LPS and the natural killing (NK) cell activity of mice decreased in some degree after radiotherapy, but the average tumor weight decreased more obviously in radiotherapy + medicine groups (compared with tumor control group, P 0.05); and the other above indexes were much higher in radiotherapy + medicine groups than those in radiotherapy groups (P 0.05–0.01). Conclusion: It was suggested that JQM can enhance the effect of radiation therapy and protect the normal immune system caused by radiation therapy. Key words Jiaqi mixture; radiotherapy; blastisation of lymphocyte; NK cell activity; radioprotection Jiaqi Mixture (JQM)