促进脂肪组织工程再血管化的相关研究进展.pdfVIP

1008 Chinese Journal of Reparative and Reconstructive Surgery, August 2011, Vol. 25, No.8 · · 促进脂肪组织工程再血管化的相关研究进展 常强 潘世杰 鲁峰 【摘 要】 目的 对脂肪组织工程中再血管化的研究现状进行分析，为组织工程脂肪再血管化提供理论参 考。 方法 广泛查阅近年有关脂肪组织工程中关于再血管化研究的相关文献，围绕促血管化的 5 个方面，包括脂肪细 胞组织结构及血供系统的特殊性、血管化的机制、种子细胞的复合、支架材料的修饰、微环境的改善，进行相关文献复习 和综述。 结果 脂肪组织工程技术为修复软组织缺损提供了一条新思路，但目前构建成功的组织工程脂肪体积均未超 过 1 mL，主要与构建物内血管化程度有关，因此构建物内血供的快速重建是脂肪组织工程由基础向临床应用的关键性环 节。 结论 促进脂肪组织工程移植物尽快再血管化，能使支架上种子细胞及时获得营养，为制备大体积组织工程脂肪 提供可能，从而满足临床修复大范围软组织缺损的需要。 【关键词】 脂肪组织工程 再血管化 种子细胞 支架材料 ADVANCE OF REVASCULARIZATION OF ADIPOSE TISSUE ENGINEERING/CHANG Qiang, PAN Shijie, LU Feng. Department of Plastic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou Guangdong, 510515, P.R.China. Corresponding author: LU Feng, E-mail: doctorlufeng@ 【Abstract 】 Objective To review the research status of the neovascularization of adipose tissue engineering in the past decade so as to provide theoretical references for the development of the rapid revascularization of tissue engineered adipose. Methods The literature about the revascularization of adipose tissue engineering was extensively reviewed and analyzed, centering on 5 elements: specii city of histological structures and blood supply, revascularization mechanism, coculture of dif erent seed cells, modii cation of scaf old, and microenvironment. Results Adipose tissue engineering of ers a new solution for soft tissue defects. However, there is still the unfuli lled need in the size of engineered adipose tissue (less than 1 mL), which was determined by the degree of neovascularization in engineered tissue. Overall, rapid neovascularization in engineering tissue is a key link of experimental study changing into clinical application. Conclusion Providin