外周血循环肿瘤细胞检测的研究进展.pdfVIP

! 9 ! 2010 10 15 10 Chinese C linical Oncology, Oct. 2010, Vol. 15, No. 10 1 710038 西安 第四军医大学唐都医院肿瘤科 蒋蔚峰 综述, 张贺龙 审校 ( CTC), , CTC, CTC , ; ; ; : R733 : A : 1009- 0 60( 2010) 10- 09 - 0 Advance in the detection of c ircu lating tum or cells in p eripheral b lood JIANG Weifeng, ZHANGH elong. Departm entof Oncology, TangduH osp ital, the ourthM ilitaryM edical U niversity, X ian 710038, China Corresp onding author: ZHANGH elong, Email: zhanghelong@ m edmail. com. cn A bstract M etastasis is them ost common cause of death in cancer patients. C ircu lating tumor cells ( CT C) are essential for establish ingm etastasis and can be detected in the peripheral blood of patientsw ith a variety of solid cancers. Because of very low fre quency, these tum or cells are not easily detected using conven tional cytologym ethods. Th is article review s the most recent find ings on this subject, and d iscusses the problem s and prospects in th is research area. K eyW ords C ircu lating tumor cells; Tum orm arkers; Neoplasm m etastasis; Detection technique , ; , CTC [ 1] 6 7 , 10 ~ 10 1 , CT C , , , , CTC ( M icrom etastasis) , CTC , , , ( circu lating , tumor cells, CT C) , 1869, A shworth , , CTC , CTC [2] , , CTC 1 CTC CT C , 11 以形态学为基础的富集