松木刨花和枫木刨花水提取物对小鼠骨髓红细胞的影响_莫梅英.pdfVIP

25 3 Vol125 No13 250 2007 6 JOURNAL OF GUA NGDONG MEDICAL COLLEGE Jun. 2007 1 2 2 莫梅英 , 冷 扬 , 张 志 ( 1. ; 2. , 524023) : 目的 方法 80 NIH 8 , 10 3 1005012. 5 g/ kg , 3 1005012. 5 g/ kg , 1 ( ) 50 mg/ kg , 1 ( ( ) , 24h 6 h , , 结果 ( P 0. 0 1) , ( P 0. 05) 结论 : ; ; : R-332 : A : 1005-4057( 2007) 03-0250-03 Effect of water extractives from pine and maple paring on mouse marrow erythrocytes 1 2 2 MO M -i ying , LENG Yang , ZHANG Zhi ( 1. Morphologic Laboratory of Guangdong M dical Coll g , Zhanjiang 524023, China) Abstract: Objective T o inv stigat th ff ct of wat r xtract iv s from pin and mapl paring on mous marrow rythrocyt s by micronucl us t st. Methods Eighty NIH mic w r randomly divid d into 8 groups, w ith 10 mic in ach group. Of th 8 groups, positiv and n gativ control groups r c iv d cyclophosphamid ( 50 mg/ kg) and normal salin , r sp ctiv ly; th oth r groups w r xpos d to th w at r xtractiv s of pin or mapl paring at a dos of 100, 50 and 12. 5 g/ kg, r sp ctiv ly. T h drugs w r administ r d intragastrically onc daily for two days. T h mic w r sacrific d 6 hours aft r th s cond tr atm nt, and th polychromat ic rythrocyt s from f moral marrow w r count d. Results Th micronucl ar rat s of poly chromatic rythrocyt s in mic with pin and mapl paring xposur w r similar to thos in n gat iv control group, but significantly low r t han thos in positiv control group. Conc lusion Th wat r xtractiv s from pin and mapl paring hav not any pot ntial mutag nicit y in mous marrow c lls. Key words:w at r xtract iv s from pin and mapl paring ; micronucl us t st; g notoxi