HIFU 联合相变氟碳乳剂损伤兔肝脏的二维超声实时监控.pdf

·776· GuizhouMedical HIFU联合相变氟碳乳剂损伤兔肝脏的 二维超声实时监控* 黼学黼嗽揪sso似，墓羹。紫羔二彪亨篡一 focused 摘要 目的探讨二维超声实时监控HIFU(highintensity ultrasound)，联合相变 氟碳乳剂损伤兔肝脏的可行性。方法使用同一聚焦超声换能器，辐照深度、功率一致条件下，静脉注 射等量相变氟碳乳剂(实验组)或生理盐水(对照组)后HIFU辐照兔肝脏，测量辐照靶区的灰度值、 回声增强区的大小，解剖测量凝固性坏死灶的大小。结果对照组HIFU辐照兔肝脏所产生的灰度 值、回声增强区体积和最大面积小于实验组，凝固性坏死灶的最大截面积、体积也小于实验组，能效因 子大于实验组。回声增强区最大面积与凝固性坏死灶最大截面积、体积之间存在定量关系。结论二 维超声可实时监控相变氟碳乳奔l存在条件下的HIFU损伤，相变氟碳乳卉l提高了HWU的损伤效 率。 关键词 高强度聚焦超声 氟碳化合物 乳剂 超声成像 实时监控 Reabtmne withtwo-dimensional inrabbitliver ill- mitoring ultrasonographydamagingexperiment HWU witlIa shift Xiao Yah— combiningphasepern．orope．ta他emulsionZitocn，Liu sing Liping，Xiao and Obstetrics，Tk bing，LiFaqi，WangZhibiao．DepartmcntofGynecology AffiliatedHospital Medical 550004，Guizhou，China． ofGuiyang College，Guiyang Abstract To the ofreal-time inthetwo-dimemionalul— Objectiveexplorefeasibility monitoring in focusedultrasound(HIFU)and tmsonographydamagingexperimentusinghighintensity combining with shift emulsion．Methodsaidenticaltransducer．undersa：rneradia— phase perfluoropentane Using shift andemissionpower。isovolumetric emulsion(as tingdepth phasepe胡uoropentaneexperimental saline(ascentrel torabbitliverra— group)andphysiological group)wereinjectedintravenouslyprior with scaleof secarandthreedimension diatingHIFU，respectively．Greytarget region，maximal of weremeasuredsoftwareofjcMODEHIFUTUMORTREAT— lengthhyperechoier