人参超微粉与细粉的体外溶出度比较.pdfVIP

J South Med Univ, 2013, 33(10): 1547-1550 doi 10.3969/j.issn. 1673-4254.2013.10.31 1547· · 技术方法 人参超微粉与人参超微粉与细粉的体外溶出度比较细粉的体外溶出度比较 1 2 3 2 1 蔡 璐 ，梁少瑜 ，戴开金 ，向飞军 ，罗奇志 1 3 2 南方医科大学 肿瘤研究所，产业管理处，广东 广州 510515；康美药业股份有限公司，广东 普宁 515300 摘要：目的 比较人参超微粉与细粉中人参皂苷类成分的体外溶出度，探索粉体粒径对人参皂苷类成分溶出的影响，为人参入药 时粉碎粒径的选择提供科学依据。方法采用浆法，运用高效液相色谱同时分析人参超微粉和细粉中5 种人参皂苷成分的体外 溶出情况，绘制溶出曲线，比较人参不同粒径粉末的溶出特征。结果人参超微粉与细粉相比，其人参皂苷类成分Re、Rg 1 、Rf、 Rb 1、Rb2 具有更快的溶出速度，5 min 内即能溶出总量的90%以上；人参超微粉与细粉中人参Re、Rf、Rb 1、Rb2 溶出总量无显著 性差异；人参超微粉中Rg 1溶出量较高（P0.05）；但将人参超微粉与细粉均置于袋泡茶茶袋中时，人参细粉中5种人参皂苷反而 比人参超微粉溶出快。结论超微粉碎能加快人参中人参皂苷类成分的溶出速度，提高Rg 1溶出总量，但将其装入袋泡茶茶袋中 时，人参超微粉中人参皂苷类成分反而比人参细粉溶出慢，因此在超微粉入药时，不宜选用袋泡茶剂型。 关键词：人参皂苷；溶出度；人参超微粉；人参细粉 Comparison of dissolution properties between Ginseng micropowder and common powder 1 2 3 2 1 CAI Lu , LIANG Shaoyu , DAI Kaijin , XIANG Feijun , LUO Qizhi 1Cancer Research Institute, 3Industrial Affairs Office, Southern Medical University, Guangzhou 510515, China; 2Kang Mei Pharma- ceutical Co. LTD., Puning 515300, China Abstract: Objective To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. Methods Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. Results The dissolution rates of ginsenosides from micropowder exceeded 90% within 5 min, significantly greater than that from common powder. But when the powders were packed in tea bags, the dissolution rates of ginsenosides were higher from common powder than from micropowder. Conclusion Micronization treatments can promote dissolution of ginsenosides from Ginseng. Key