妊娠相关血浆蛋白A高敏C反应蛋白与冠脉再狭窄的关系.docVIP

妊娠相关血浆蛋白A、高敏C反应蛋白与冠脉再狭窄的关系 作者：张彦红，吴桂平， 付 鑫，周 瀛 作者单位：沈阳医学院附属沈洲医院心内科，辽宁 沈阳 110002 【摘要】 目的：探讨妊娠相关血浆蛋白A（PAPP-A）。高敏C反应蛋白（hs-CRP）与经皮冠状动脉介入治疗（PCI）术后再狭窄的关系。方法：选择71例接受PCI治疗并于PCI术后6个月复查冠脉造影的患者，经冠脉造影证实出现支架内再狭窄的患者14例（再狭窄组），未出现再狭窄的患者57例（无再狭窄组），测定入选患者PCI术前和术后血浆PAPP-A，hs-CRP水平并分析其支架内再狭窄情况。结果：再狭窄组患者术后血浆PAPP-A，hs-CRP水平较无再狭窄组显著升高（P<0.01），且术后PAPP-A，hs-CRP水平与PCI术后冠脉后期内径丢失指数呈正相关（r=0.57，P<0.01）。结论：PCI术后血浆PAPP-A，hs-CRP水平可以预测冠脉再狭窄的发生。 【关键词】 妊娠相关血浆蛋白-A；C反应蛋白；血管成形术，经腔，经皮冠状动脉；冠状动脉再狭窄 Correlation of pregnancyassociated plasma protein-A and high sensitivity C-reactive protein with restenosis after percutaneous coronary intervention/ZHANG Yanhong, WU Guiping, FU Xin, ZHOU Ying//Chinese Journal of Cardiovascular Rehabilitation Medicine,2009,18(2):122 Abstract：Objective:To investigate the relationship between plasma pregnancyassociated plasma protein-A（PAPP-A）,high sensitivity C-reactive protein(hs-CRP) and restenosis after percutaneous coronary intervention(PCI).Methods:A total of 71 patients performed PCI and followed by repeated angiography 6 months after PCI were selected. Their baseline and followup angiograms were compared by quantitative coronary angiography to assess incidence of restenosis. They were assigned in restenosis group(n=14)and no restenosis group (n=57)by angiography. Plasma PAPP-A and hs-CRP were measured before and after PCI.Results:The level of plasma PAPP-A and hs-CRP in restenosis group were significantly higher than that in no restenosis group after PCI (P<0.01).The later loss index of coronary artery lumen diameter was positive correlated with plasma PAPP-A and hs-CRP after PCI (r=0.57,P<0.01).Conclusion:Plasma PAPP-A and hs-CRP level after PCI possibly forecasts the occurrence of restenosis after PCI. Author′s　address： Department of Cardiology,Shenzhou Hospital of shenyang Medical College,Shenyang,Liaoning,110002,China Key words：Pregnancyassociated plasma protein-A；C-reactive protein；Angioplasty,transluminal