新药物治疗阿尔茨海默病和帕金森病效果与影响的思考.docVIP

新药物治疗阿尔茨海默病和帕金森病效果与影响的思考 阿尔茨海默病和帕金森病是一种进行性神经退化紊乱疾病，至今还没有能够治愈的方法，研发新的治疗方法需求已经十分明显，目前为止，该行业在寻找新的药物治疗方面已投资数十亿美元。然而，特别是对阿尔茨海默病的尝试中，仍没有任何显著进展，并且一系列的临床试验也未出现任何改进，这打击了一些制药公司从投资到进一步研究的积极性。激活患者免疫系统或用针对淀粉样蛋白的特异性抗体除去β-淀粉样蛋白的免疫应答策略没有得到显著疗效；减少β-和γ-分泌产生淀粉样蛋白也遭遇了一系列挫折。虽然这两种主要治疗策略都没有成功，但另一种治疗方法在相当长的时间里已显示出可喜的成果。这种方法不仅着眼于将淀粉样蛋白水平作为生物标志物，使用生长因子支持细胞修复已经显示出了有希望的疗效。 英国兰卡斯特大学的Christian H?lscher教授指出，生长因子信号去敏化已被证明存在于患有阿尔茨海默病或帕金森病患者的大脑中。产生这种现象的原因还不完全清楚，但它很可能是由这些神经退行性疾病发展过程中带来的慢性炎症引起的。利用生长因子类似物能够穿越血脑屏障的策略，这一方法是值得关注和投资的，资金的缺乏阻碍了新的治疗方法的测试，并且目前对这2中病的治疗已经需要开始重新思考转变目前的研究策略方向上了。相关研究内容发表在2014年11月第21期《中国神经再生研究（英文版）》杂志上。 Article: New drug treatments show neuroprotective effects in Alzheimer’s and Parkinson’s diseases by Christian H?lscher (Neuroscience research group, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK) H?lscher C. New drug treatments show neuroprotective effects in Alzheimer’s and Parkinson’s diseases. Neural Regen Res. 2014;9(21):1870-1873. 欲获更多资讯： New drug treatments show neuroprotective effects in Alzheimer’s and Parkinson’s diseases Alzheimer’s and Parkinson’s diseases are a progressive neurodegenerative disorder for which we do not have a cure. There is a clear need for novel treatments, and the industry has invested billions of dollars in finding new drug treatments. However, in particular in Alzheimer’s disease, the efforts have been in vain, and a string of clinical trials that did not find any improvements have discouraged some drug companies from investing into further research. The immune response strategy to remove beta-amyloid by activating the patient’s immune system or with the help of specific antibodies directed against amyloid had a string of failures. The second strategy to reduce the activity of the beta- and gamma-secretases that produce amyloid also has suffered a series of setbacks: avagacestat. While these two main strategies have not been successful, another strategy has shown promising results for a fairly long time now. Instead o