常用软膏剂的制备.docVIP

常用软膏剂的制备 ????????????????????????????????????????? ??0542327 仝贇 ??????????????????????????????????????Preparation of ointments ??? Ointments are semi-solid preparations made of medicaments and suitable bases, which are intended for external application to the skin. Ointment bases recognized for use as vehicles distinguished into three general classes: the oleaginous bases, the emulsion bases, and the water –soluble bases. ??? There are three general methods: the method of grinding and mixing, the method of melting and mixing, the method of emulsification. ??? Ophthalmic ointments are ointments for application to the eye whose bases general include liquid paraffin, Vaseline and wool fat. Special precautions must be taken in the preparation of ophthalmic ointments. They are manufactured from sterilized ingredients under rigidly aseptic conditions. The ointment base that is selected must be without any irritation to eye. ? Equipments: evaporating, water bath, electric furnace, analytical balance, thermometer, microscope etc. ? Materials: Stearic acid, glycerol monostearate, Vaseline, glycerol, liquid paraffin, triethanolamine, calcium hydroxide, CMC-Na, span80, nonoxynol-10, distilled water etc. Procedures: ? 1.?????? O/W emulsion base ?Formulation Stearic acid???????????? 4.8g Glycerol monostearate??? 1.4g Liquid paraffin?????????? 2.4g Vaseline??????????????? 0.4g?????? To keep water Wool fat??????????????? 2.0g Triethanolamine????????? 0.16g Distilled water add up to?? 40.0g ? Preparation: ??? Add stearic acid, glycerol monostearate, liquid paraffin, Vaseline and wool fat into evaporating dish, which the mixture is used as oil phase. Add triethanolamine and distilled water into beaker, which the solution is used as a water phase. The two containers are heated to 80°C in water bath and kept until melting completely. Pour oil phase into water phase slowly, and stir them fully. Cool at room temperature, then the O/W emulsion base can be got. 2.?????? ?W/O emulsion base