氟伐他汀对急性心肌梗死后左室重构的实验研究.docVIP

氟伐他汀对急性心肌梗死后左室重构的实验研究 　　作者：邵博一 　　[摘要] 目的 观察氟伐他汀对急性心肌梗死兔早期左室重构和心功能的影响。评价C反应蛋白(CRP)对心肌梗死后左室重构的预测价值。方法 将梗死后24 h存活兔随机分成：AMI模型组(M组，n=11)，AMI氟伐他汀组(F组，n=12)，另设假手术组(S组，n=10)。给药2周后，测血流动力学参数，比较各组间左室重构各指标。 结果 与假手术组相比，AMI模型组左室舒张末压(LVEDP)、左室重量(LVW)、左室重量指数(LVWI)、血CRP均显著增加(P0.05)，左室收缩压(LVSP)、左室内压最大上升和下降速率(±dp/dtmax)均显著降低(P0.05)。与AMI模型组相比，AMI氟伐他汀组LVEDP、LVW、LVWI、血CRP均显著降低(P0.05)，LVSP、±dp/dtmax均显著增加(P0.05)。结论 氟伐他汀减少心梗后CRP的作用可能是其减轻急性心肌梗死后早期左室重构的机制之一。高浓度血CRP是预测心肌梗死急性期发生心室重构的预测因素。 　　[关键词] 氟伐他汀;心肌梗死;心室重构;C反应蛋白;兔 　　Study of fluvastatin on primary ventricular remodeling and heart function after experimental acute myocardial infarction 　　SHAO Boyi.Department of Cardiology，the Fourth Hospital of Xuzhou，Jiangsu 221009，China 　　[Abstract] Objective To observe the effect of fluvastatin on primary ventricular remodeling and heart function after experimental acute myocardial infarction.To assess the prognosis value of serum Creactive protein (CRP) in postacute myocardial infarction(AMI) left ventricular remodeling.Methods By ligation of coronary artery，AMI model of rabbits was established.24 hours after the operation，the survival rabbits were randomly assigned to AMI model group (n=11);fluvastatin group(n=12)，shamoperated rabbits (n=10) were selected at random，and were treated by gavage fluvastatin(10 mg/kg/d) or distilled water.After two weeks of treatment，the changes of the hemodynamics was observed，and plasma CRP and ventricular remodeling were measured.Results Compared with group S，LVEDP，LVW，LVWI，CRP level were significantly higher(each P0.05)，and LVSP，±dp/dtmax were significantly lower(each P0.05)in group M.Compared with group M，LVEDP，LVW，LVWI，CRP level were significantly lower.(each P0.05).And LVSP，±dp/dtmax were significantly higher(each P0.05) in group F. Conclusion Fluvastatin could improve primary ventricular remodeling and heart function after myocardial infarction.High CRP level is a predictor of left ventricular remodeling in the early phase of AMI. 　　[Key wor