甲状腺激素水平与冠心病严重程度的相关性研究.docVIP

甲状腺激素水平与冠心病严重程度的相关性研究 　　作者：王冬莲，梅丽萍，卢先本，何小帆，廖 辉 作者单位：台州医院，浙江临海 　　【摘要】 目的 研究甲状腺激素水平与冠心病及其病变严重程度的关系。方法 将225例行冠状动脉造影的患者按造影结果分为冠心病组和正常对照组，用Gensini评分系统评价冠状动脉损害严重程度。冠心病组又按照临床表现、心电图等分为冠心病心衰组和冠心病非心衰组。分别测定血清甲状腺激素水平与血脂水平。结果 冠心病合并心衰组总三碘甲腺原氨酸和游离三碘甲腺原氨酸均小于正常对照组。运用多元逐步回归分析，甲状腺激素均未被引入方程。结论 甲状腺激素并不与冠心病的严重程度独立相关，但总三碘甲腺原氨酸和游离三碘甲腺原氨酸与冠心病合并心衰有关。冠心病患者应检查其甲状腺激素水平，对甲状腺激素水平低者应积极防止其并发心力衰竭。 　　【关键词】 冠心病;甲状腺激素;Gensini评分系统 　　The Relationship between Thyroid Hormone Levels and the Coronary Artery Disease. WANG Dong_lian, MEI Li_ping, LU Xian_ben, et al. Taizhou hospital, Zhejiang 317000, China 　　[Abstract] Objective To explore the relationship between thyroid hormone levels and the severity of coronary heart disease (CHD). Methods 225 patients were divided into CHD group and control group according to coronary artery angiography. The severity of coronary artery stenosis was evaluated and scored by Gensini coronary scoring system. According to the clinical manifestation, ECG, et al, the patients in CHD group were again divided into CHD with heart failure subgroup and CHD without heart failure subgroup. The serum thyroid hormone levels and the serum lipid levels were measured in all patients. Results The levels of total triiodothyronine and free triiodothyronine in CHD with heart failure group were significantly lower than those in control group. Using stepwise multiple regression analysis, none of thyroid hormones was introduced equation. Conclusions None of the thyroid hormones was an independent risk factor for the severity of CHD, but the total triiodothyronine and free triiodothyronine were associated with heart failure in CHD. The CHD patients should be examined their thyroid hormone levels, the thyroid hormone should be given to prevent concurrent heart failure in low thyroid hormone levels patients. 　　[Key words] Coronary heart disease; Thyroid hormone,;Gensini scoring system 　　甲状腺激素包括甲状腺细胞分泌的四碘甲腺原氨酸(T4，又称甲状腺素)和三碘甲腺原氨酸(T3)，其与冠心病的关系[1，2]，目前仍有争议。本研究旨在通过对冠状动脉造影证实的冠心病患者