高血黏度大鼠血液有形成份及血液流变性的动态观察.pdfVIP

·104· 文章编号：1007-8568(2005)02-0104—04 ·实验研究· 高血黏度大鼠血液有形成份 及血液流变性的动态观察 樊 勇，白德成 【摘要】 目的检测高分子右旋糖酐法致高血黏度大鼠模型血液有形成份及血液流变性指标， 寻找其变化规律并分析原因。方法将大鼠随机分为高血黏度模型组和空白对照组，连续检测模型组动 物10日内全血黏度、血浆黏度、血沉、血浆纤维蛋白原及血液有形成份的变化。结果与对照组比较，模 型组大鼠自细胞、红细胞、红细胞比容、血红蛋白和血小板逐渐减少一全血黏度升高一血浆纤维蛋白原 和血浆黏度呈正相关增高趋势一血沉增快非常明显，5d后保持在极快水平。结论高分子右旋糖酐可 引起全血黏度及血浆黏度升高，红细胞破坏，红细胞比容和血红蛋白含量降低，白细胞和血小板附壁，红 细胞聚集性增强。 【关键词】大鼠模型；高血黏度；有形成份；血液流变学 中图分类号：R331．1 文献标识码：B The onBlood and in Blood Rats HemorheologyHigh Viscosity ExperimentalStudy Components FAN I Yong,BADe-cheng．LanzhouUniversity,Lanzhou，Gansu,730000,China To ofthevisible and of bloodvi- detectindexes 【Abstract】Objective componentshemorheologyhigh forthelawof and causes．MethodsRatswere ratsmodel dextran，look scosity byhishpolymer changesanalyze dividedinto blood andthenormalcontrol blood randomly high viscositygroup group．Wholeviscosity，plasma andvisible weredetermined in10 components continuouslydays viscosity，erythmcytesedimentation，fibfinogen and withthenormalcontrol and compared group．Results reduced blood increased．Thecontentsof and in- platelet obviously．Wholeviscosity fibfinogenplasmaviscesty creased and were sedimentation fastandWas fast obviouslythey proportional．Erythrocyte changedvery keeping levelafterfive dextranCanincreasewholeblood and visces- days．ConclusionsHighpolymer viscostyplasma dextranCan causehematooritand toreduce．Leuco— 畸．Hishpolymer damageerythrocyte，this ferrohemoglobin and onen