黄原胶分子自组装行为原子力显微镜研究.pdfVIP

河南大学光学专业2006 级硕士论文 摘要 黄原胶（Xanthan gum），是分子量很大的一种多糖，因其无毒副作用和生物 相容性而可应用作药物载体、进行控制药物释放，达到靶向定标的目的。本论文 利用轻敲模式原子力显微镜（AFM ）对不同条件下的黄原胶分子自组装进行研 究，结果发现黄原胶溶液浓度较高时，自组装结果是球状的颗粒，以多聚体形式 存在；然而，在一定的浓度下，黄原胶能够通过自组装形成稳定的网状结构；在 浓度低的情况下却形成了单个纤维分子。本文中提出了黄原胶分子从网状结构到 单个纤维形成过程的假设模型，很好地解释了实验观察结果。此外，论文还研究 了黄原胶在不同退火温度、退火时间、超声效应和pH 值条件下的自组装行为。 论文主要由三个部分组成： 第一部分介绍了黄原胶的基本知识和研究状况，并由此引出本论文的研究目 标和研究内容； 第二部分详细介绍了试验中主要所用到的原子力显微镜； 第三部分是实验部分，系统的研究了黄原胶在不同溶液的浓度、退火温度、 退火时间、超声效应和pH值条件下的自组装行为。 关键词：黄原胶；原子力显微镜；退火；超声；自组装 I I 河南大学光学专业2006 级硕士论文 Abstract Xanthan gum is a kind of polysaccharide with high molecular weight; it can be applied to the field of drug carrying and controlled drug releasing for targeted drug releasing because of its no-toxic and biological compatibility properties. Investigation of Self-Assembly of Xanthan Gum at different conditions by tapping mode atomic force microscopy (AFM) were carried out here, and the results showed that the xanthan gum molecules aggregated together and formed particles at hight concentration, network at lower concentration, and single fiber at the lowest concentration. A hypothesis model was built to illustrate the formation process from network to single fiber of xantha gum moleculars. The self- assembly of xanthan gum at different annealing temperature, ultrasonic effect and pH value were also studied in this thesis . There are 3 parts in this thesis. 1. In the first part, xanthan gum was introduced and the aim of this thesis was brought up; 2. AFM was introduced in the second part. 3. The third part described the experiment s in detail, the self- ass