DataPreprocessingandOutputEvaluationofanAutoassociative.pdf

JOURNALOF BIOSCIENCEAND BIOENGINEPRING Vol.94,No.I,70-77.2002 Data Preprocessing and Output Evaluation of an Autoassociative Neural Network Model for Online Fault Detection in Virginiamycin Production JIHUA HUANG,’ HIROSHI SHIMIZU,’ AND SUTEAKI SHIOYA’* Department of Biotechnology, Graduate School of Engineering, Osaka University Suita, Osaka 5654871, Japan’ Received 6 March 2002/Accepted 7 May 2002 In this study, an artificial autoassociative neural network (AANN) was used online to detect de- viations from normal antibiotic production fermentation using conventional process variables. To improve the efficiency of extracting hidden information contained in multidimensional process variables, and to finally render the AANN adequate for fault detection, we explored the following methods: selection of process variables; preprocessing of data that involved normalizing the train- ing data of the AANN; and evaluation of data that involved assessing the output of the AANN. A method for fault detection in virginiamycin M and S production by Streptomyces virginiae was successfully developed based on these techniques. [Key words: faul