银杏叶总黄酮脉冲缓释胶囊体外释放度实验研究_鄂蕴娟.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 09年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 鄂蕴娟, 赵令竹, 龙沛霞 (, 110032) :通过建立了银杏总黄酮缓释胶囊体外释放 测定方法,确定该胶囊体外释放 测定条件为: 0. 2%吐 温 80的 2% 盐酸溶液为溶剂,转速为每分钟 50转, 2h后向操作容器中补加磷酸盐缓冲液调节 pH值至 5. 8, 4h后 加磷酸盐缓冲液调节 pH 至 7. 0; 共计测定 5批样品 8h 内银杏总黄酮释放量规定本品每粒在 2h4h与 8h银杏 总黄酮的释放量应为样品实测量的 15% ~ 45%45% ~ 75%和 70% 以上 :银杏叶总黄酮; 缓释; 体外释放 : R285. 5 : A : 1673- 7717( 2009) 12- 2669- 02 ExperimentalResearch on the Release Degree in Vitro of Pulse Sustained- Release Capsules of Total Flavonoids of Ginkgo B ilo a Leaf E Yun-juan, ZHAO L ing-zhu, LONG Pe-ixia ( L iaoning University ofT raditional hinese M edicine, Shenyang 110032, L iaoning, hina) Abstrac:t In this paper, w e have established a method of total flavonoids of G inkgo biloba in vitro release of sus- tained- release capsule, a com firmative method of determ ine conditions of capsule release in vitro: 0. 2% tw een 80 of 2% hydrochloric acid as the solvent, speed50 perminute, reinforced the phosphate buffer added to the operation of con- tainer after 2 hours and adjusted pH value to 5. 8, put in the phosphate buffer after 4 hours and adjusted pH value to 7. 0; determ ined 5 approved sample in totalof flavonoids of G inkgo biloba release amount in 8 hours. Defined any pill total fla- vonoids of G inkgo release amountwhich measured up to 15% ~ 45% , 45% ~ 75% and 70% above of the sample fact measured at2 hour, 4 hour and 8 hour. Key w ords: total flavonoids of G inkgo biloba; sustained- release; release degree in vitro , 6 ,, ( h ) ( mg) ( g)