NK细胞的发育_分化与识别机制.pdfVIP

　NK 、　 1 ·31 · NK 、 　　(中国科学技术大学免疫学研究所, 合肥230027) 　　　R392.11　　　A　　　1000-484X(2009)01-0031-04 [　] 　NK NK (NK cell precursors,NKPs)。NKPs, (Early lymphoid precursors, ELPs)NKPs。、、NKPs, NK 。NKPs 、、、;NKPs 。NKPs NK (iNKs), “education” NK (mNKs)。iNKs mNKs “MHC Ⅰ”“education”mNKs , “MHC Ⅰ”“education”NK 。NK , NK 。NK , NK NK NK (NK1, NK2, NK3), NK (NKreg)NK (NKDC)。NK lung li er blood spleen bone marrow lymph node thymus。NK (、 )“”, NK 、, , 。 [] 　NK ;;; Development,differentiation and immune recognition of natural killer cells TIAN Zhi-Gang , CHEN Yong -Yan .Institute of Immunology , University of Science Technology of China , Hef ei 230027, China [A stract] 　Natural killer (NK)cells come from NK cell precursors (NKPs).The heamatopoietic stem cells of bone marrow may de el- op into NKPs.The early lymphoid precursors (ELPs)in thymus may also differentiate into NKPs.NKPs are found in li er, lymph node and spleen, indicating these tissue or organs may supply the microen ironment for NKPs differentiation.NKPs from bone marrow may migrate into thymus,lymph node, li er and spleen.NKPs in thymus can mo e to lymph nodes for further differentiation.NKPs need to differentiate into im- mature NK cells (iNKs),which then become mature NK cells (mNKs),followed by a series of “education”.During differentiation of iNKs into mNKs,the mNKs acquire at least one kind of inhibitory receptor ia “self-MHC-I education”, or express other immune receptors without “self- MHC-I education”.The array and balance of inhibitory receptors and triggering receptors on mNKs determine the final acti ation and function of mNKs.In addition to the classic killing function of NK cells,the NK subsets may di ide into helper NK cells (NK1, NK2, NK3),regulatory NK cells (NKreg)and Ag-presenting NK cells (NKDC), based on the roles of NK cells in immune response.The distribution of NK cells is as fol- lowed:lu