N乙酰半胱氨酸治疗慢性阻塞性肺病急性发作期疗效观察.pdfVIP

塾匿医堂塞鲞兰QQ2生箜i鲞筮三翅(土) N一乙酰半胱氨酸治疗慢性阻塞性肺病急性发作期 疗效观察 ’ 仝金斋左万里黄炎明梁丽萍(江门市中心医院呼吸科广东江门529000) [摘要]目的观察应用N一乙酰半胱氨酸治疗慢性阻塞性肺病急性发作期(AEc0PD)患者的疗效。方法 将76例AEc0PD随机分为治疗组和对照组各38例，患者均酌情使用茶碱缓释剂及抗生素治疗，治疗组在此基础上给 予口服N一乙酰半胱氨酸颗粒剂治疗，每次200mg，每日三次，均于餐后服用，疗程14d。对照组不给予口服N一乙酰 半胱氨酸颗粒剂治疗，观察治疗前后两组患者咳嗽、咳痰、气促症状等临床症状及肺功能变化情况、结果 治疗组患 2组比较有显著性差异，(P0．05)。治疗组FEVl改善较对照组明显(PO．05)。结论N一乙酰半胱氨酸用于 AECOPD患者可以减轻气流阻塞，防止氧化应激，改善患者的呼吸功能，且使用安全。 [关键词]N一乙酰半胱氨酸；慢性阻塞性肺疾病；氧化应激 [中图分类号]R563．9[文献标识码]A[文章编号]1672—4208(2007)03—0026一03 TreatmentofAECoPDwith N—acetylcystei耻 ce，础，uf^osp：￡oZq厂胁rzgm_enCif_y，。^Ⅱ，lg，rLen529000，C危inn T0 theeffectofAECoPDwith 76 【Abstract】objectinvestigate pa— tientsweredividedintotwo contained38 A11 weretreatedwith groupsra矗domlv，eachgroup patients．patients Sl()w—I．elease orantibioticwhile need．The were theophvline patients treaⅡnent卿upsgiven times Thecourseoftreatmentwas14 Contr01 werenot granulatedpowder，threedailv． days． grouppatients given 0bsen，ethe of and N—acetylcysteinegranulatedpowder． change cough，expectomtion，dyspneicsymptom FEVlin In have22caseclinic 1 case patients．Resllltstreatment挈Toup symptomimprovementsignificantly，1 clinic Totalef玷ctiverateis86．84％．In have11 caseclinic im— symptomimprovement． control盯ouD svmptom 6caseclinic ef]fectiverateis71．05％．Two were proVements远nificantly，l symptomimpr0Vement．Tbtal groups dif玷rence in IN FEVlweremore thanincon— sign讯cantlvstatistics(P0．05)．treatment舯up improvement