CyclinE的表达和乳腺癌的预后的meta分析.pdf

200 1 7 CH INA ONCOLOGY 200 Vol. 1 No. 7 525 Cyclin E的表达和乳腺癌的预后的m eta分析 1 1 2 1 1 1 1. , , 200032; 2. , 200032 [ ] : cyclin E, , E( cyclin E) : PubM ed CBMDisc cyclin E , m eta cyclin E: 13, 2 44 , cyclin E ( RFS) ( HR) 2. 2 ( 95% CI: 1. 4 1 3. 1) 1. 72( 95% C I: 0. 953. 10); cyclin E ( OS) / ( BCSS)HR 2. 74( 95% C I: 2. 223. 39) 2. 8 ( 95% C I: 1. 854. 41), cyclin E OS HR 3. 40( 95% C I: 2. 205. 2 ): cyclin EOS, [ ] ; ; E; m eta : R730. 7 : A : 10073 39( 200 ) A m etaanalysis of cyclin E and its impact on the prognosis of breast cancer patients WAN G L ei, FAN J iang, WANG X iaoj in, D I Genhong, SH EN Zhenzhou, SHA O Zh im in (D ep artm ent o B reast Sur g ery, CancerH osp ita,l Fudan University. D ep artm ent o Oncology, Shang haiM edical C olleg e, Fudan Uni versity, Shang hai200032, Ch ina ) Corresp ondence to: SHA O Zh im in E mail: zh im ingshao@ yahoo. com [Abstract] Background and purpose: It has been confirm ed that cyclin E cou ld accelerate the cell cycles by in vitro stud ies. Therefore, various stud ies have investigated the relationsh ip between cyclin E and survival in breast cancer pa tients. H ow ever, the results d iffered sign ifican tly from study to study. To determ ent whether cyclin E is an independent prognostic factor for breast cancer, w e com pleted am etaanalysis of the published literature. M ethods: A ll data that w ere as sociated w ith the study of the relationship betw een cyclin E and the prognos is for breast cancerw aspooled from PubM ed and CBM disc database. To m easure the outcom ew e used the hazard ratio (HR). T