富马酸氯马斯汀注射液作为粒细胞输注引起的过敏反应的预防性用药.pdfVIP

Support Care Cancer (2006) 14: 910–916 DOI 10.1007/s00520-006-0041-x ORIGINAL ARTICLE Lorenz Grigull G-CSF mobilised granulocyte transfusions Nicole Pulver Lilia Goudeva in 32 paediatric patients with neutropenic Karl-Walter Sykora Christin Linderkamp sepsis Andreas Beilken Kathrin Seidemann Hansjörg Schmid Karl Welte Hans-Gert Heuft Received: 14 October 2005 Abstract Introduction: In this ret- suspected or proven infection). In ten Accepted: 8 February 2006 rospective, uncontrolled, observa- children bacteria were isolated, in six Published online: 19 April 2006 tional study, the effect of granulocyte children a fungal infection was diag- # Springer-Verlag 2006 colony-stimulating factor (G-CSF)- nosed and four sepsis episodes were stimulated granulocyte transfusions caused by viral infections. GTX (GTX) in neutropenic paediatric pa- contained a median neutrophil num- tients with sepsis was evaluated. ber of 6.3 (range 1.9– 13.9)×1010 per Patients and methods: Granulocytes transfusion and obtained a sustained L. Grigull (*) . N. Pulver . were collected from unrelated, ABO haematological response after GTX. K.-W. Sykora . C. Linderkamp . group-matched and cytomegalic-anti- Nineteen out of 32 children survived A. Beilken . H. Schmid . K. Welte body compatible donors. For neutro- the neutropenic sepsis, particularly Department of Paediatric Haematology phil mobilization, donors received a nine out o