《Local administration of icariin contributes to peripheral nerve regeneration and functional recovery》.pdfVIP

NEURAL REGENERATION RESEARCH January 2015,Volume 10,Issue 1 SPECIAL ISSUE Local administration of icariin contributes to peripheral nerve regeneration and functional recovery 1, # 2, # 3 2 1 1 1 1 1, * Bo Chen , Su-ping Niu , Zhi-yong Wang , Zhen-wei Wang , Jiu-xu Deng , Pei-xun Zhang , Xiao-feng Yin , Na Han , Yu-hui Kou , Bao-guo Jiang1, * 1 Department of Trauma and Orthopedics, Peking University People’s Hospital, Beijing, China 2 Beijing Shijitan Hospital, Capital Medical University, Beijing, China 3 Health Science Center, Peking University, Beijing, China Abstract *Correspondence to: Our previous study showed that systemic administration of the traditional Chinese medicine Yu-hui Kou, M.D., Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the ther- yuhuikou@. apeutic effects of local administration of icariin, a major component of Epimedium extract, on Bao-guo Jiang, M.D., peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used jiangbaoguo@. to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the # These authors contributed equally to defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers this work.