《Local inhibition of GABA affects precedence effect in the inferior colliculus》.pdfVIP

NEURAL REGENERATION RESEARCH February 2014,Volume 9,Issue 4 Local inhibition of GABA affects precedence effect in the inferior colliculus 1 1 1 2 1 2 1 1 Yanjun Wang , Ningyu Wang , Dan Wang , Jun Jia , Jinfeng Liu , Yan Xie , Xiaohui Wen , Xiaoting Li 1 Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China 2 Department of Neurophysiology, Capital Medical University, Beijing, China Abstract Corresponding author: The precedence effect is a prerequisite for faithful sound localization in a complex auditory envi- Ningyu Wang, M.D., Department of Otorhi- ronment, and is a physiological phenomenon in which the auditory system selectively suppresses nolaryngology Head and Neck Surgery, Beijing the directional information from echoes. Here we investigated how neurons in the inferior col- Chaoyang Hospital, Capital Medical Universi- liculus respond to the paired sounds that produce precedence-effect illusions, and whether their ty, Beijing 100020; College of Otolaryngology, firing behavior can be modulated through inhibition with gamma-aminobutyric acid (GABA). Capital Medical University, Beijing 100069, We recorded extracellularly from 36 neurons in rat inferior colliculus under three conditions: China; Key Laboratory of Otolaryngology no injection, injection with saline, and injection with gamma-aminobutyric acid. The paired Head and Neck Surgery, Capital Medical Uni- sounds that produced precedence effects were two identical 4-ms noise bursts, which were deliv- versity, Ministry of Education, Beijing 100069, ered contralaterally or ipsilaterally to the recording site. The normalized neural responses were C