97-2016哥伦比亚Electrokinetic flow control for.pdfVIP

INSTITUTE OF PHYSICS PUBLISHING JOURNAL OF MICROMECHANICS AND MICROENGINEERING J. Micromech. Microeng. 12 2002 870–877 PII: S0960-1317 02 37806-9 Electrokinetic ?ow control for composition modulation in a microchannel 1 2 3 Zhongliang Tang , Seungbae Hong , Djordje Djukic , Vijay Modi2 1 1 , Alan C West , James Yardley and Richard M Osgood3 1 Department of Chemical Engineering, Columbia University, New York, NY 10027, USA 2 Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA 3 Department of Electrical Engineering, Columbia University, New York, NY 10027, USA Received 7 June 2002, in ?nal form 23 August 2002 Published 3 October 2002 Online at stacks.iop.org/JMM/12/870 Abstract A numerical and experimental study of the injection into a microchannel of a ?uid with a spatially modulated composition is presented. The investigation employs test structures constructed in polydimethylsiloxane by standard replica molding. Fluid-?ow simulations are compared to ?ow results obtained by ?uorescence microscopy experiments. Results show that for a given channel dimension, the desired modulation of the solution composition is only possible below a threshold frequency. The value of the threshold frequency is dependent on channel size as well as ?ow rate. Experimental results are in accord with numerical simulations and theoretical considerations. List of symbols 1. Introduction V 0 potential applied between reservoirs 1 and 3 or 2 and Micro?uidic devices can be used for the delivery of drugs, 3, V chemicals and biological molecules in small, carefully potential ?eld, V controlled quantities. Sample injection techniques have been E electric ?eld, V cm?1 demonstrated using various types of cross [1–3] and double- u velocity, μm s?1 T injectors [3–5]. T-injectors are attractive when combined μeo electroosmotic mobility, m2 V?1 s?1 with a ?oating potential applied to one of the inlet reservoirs [6]. C sample