《普拉格雷FDA_label》.pdf

HIGHLIGHTS OF PRESCRIBING INFORMATION - Non-ST-segment elevation ACS (UA/NSTEMI): 300 mg loading dose These highlights do not include all the information needed to use followed by 75 mg once daily, in combination with aspirin PLAVIX safely and effectively. See full prescribing information for (75-325 mg once daily) PLAVIX. - STEMI: 75 mg once daily, in combination with aspirin (75-325 mg once daily), with or without a loading dose and with or without PLAVIX (clopidogrel bisulfate) tablets thrombolytics Initial U.S. Approval: 1997 • Recent MI, recent stroke, or established peripheral arterial disease: 75 mg once daily (2.2) WARNING: DIMINISHED EFFECTIVENESS IN POOR DOSAGE FORMS AND STRENGTHS METABOLIZERS Tablets: 75 mg, 300 mg (3) See full prescribing information for complete boxed warning. • Effectiveness of Plavix depends on activation to an active metabolite CONTRAINDICATIONS by the cytochrome P450 (CYP) system, principally CYP2C19. (5.1) • Active pathological bleeding, suc