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《Carbon nanotubes as functional excipients for nanomedicines1 》.pdf
Available online at
Nanomedicine: Nanotechnology, Biology, and Medicine 4 (2008) 173 – 182
Review Article: Nanomaterials
Carbon nanotubes as functional excipients for nanomedicines:
I. pharmaceutical properties
Marianna Foldvari, PhD, DPharmSci,a,⁎ Mukasa Bagonluri, MScb
aSchool of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada
b College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Abstract Carbon nanotubes (CNTs) are considered potential biomedical materials because of their flexible
structure and propensity for chemical functionalization. In the first part of this two-part review we
focus on the properties and use of CNTs as building blocks for novel drug delivery systems, dosage
forms, and biomedical substrates. Pharmaceutical excipients have been regarded as inert or nonactive
components of dosage forms, but they are essential and necessary components of pharmaceutical
preparations. Here we present a collection of data to initiate the description of CNTs as
pharmaceutical excipients. We summarize the synthesis, purification, and analysis of CNTs related to
their pharmaceutical properties and quality control. Application of CNTs in biological systems
depends on their compatibility with hydrophilic environments; th
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