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《Carbon nanotubes as functional excipients for nanomedicines2》.pdf
Available online at
Nanomedicine: Nanotechnology, Biology, and Medicine 4 (2008) 183 – 200
Review Article: Drug Delivery
Carbon nanotubes as functional excipients for nanomedicines:
II. Drug delivery and biocompatibility issues
Marianna Foldvari, PhD, DPharmSci,a,⁎ Mukasa Bagonluri, MScb
aFaculty of Science, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
b College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Abstract Carbon nanotubes (CNTs) have potential novel application in nanomedicine as biocompatible and
supportive substrates, and as pharmaceutical excipients for creating versatile drug delivery systems.
In the second part of this two-part review we focus on the application of CNTs as potential drug
delivery systems via chemical functionalization of CNTs for exterior binding of therapeutic and
biologically relevant molecules, and via encapsulation of these molecules within the inner cavities of
CNTs. We review experimental results of CNT-mediated delivery of small molecules, DNA,
proteins, and vaccines, and the potential of CNTs as matrices to support and stimulate neural growth.
Last, we examine some toxicological and biocompatibility issues related to the use of CNTs as
pharmaceutical excipients and discuss attributes that affect toxicity, such as str
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