蒙古黄芪化学成分研究.pdfVIP

实用药物与临床 2010年第 13卷第 2期 Practical Pharmacy And linicalRem edies, 2010, Vol. 13, N o. 2 115 温宇寒,程 亮, 郑 丹, 黄学石, 韩 力* [ ] 研究蒙古黄芪的化学成分 采用硅胶柱色谱凝胶柱色谱方法 行分离纯化, 利 用波谱分析法结合理化性质确定化合物结构 从蒙古黄芪的乙酸乙酯和正丁醇萃取部分中共分离得到 14个化合物, 分别鉴定为( 6aR, 11R )9, 10二甲氧基紫檀烷3OD葡萄糖苷( 1), ( 3R )2 羟基3 , 4 二甲氧基 异黄烷7OD葡萄糖苷( 2) , 5 羟基3 甲氧基异黄酮7OD葡萄糖苷 ( 3), 芒柄花苷( 4), ( 6aR, 11R )3羟 基9, 10二甲氧基紫檀烷( 5), ( 3R )7, 2 二羟基3 , 4 二甲氧基异黄烷 ( 6), 5 , 7二羟基3 甲氧基异黄酮 ( 7), 芒柄花素 ( 8) ,黄芪甲苷( 9), 黄芪皂苷 II( 10), 蔗糖 ( 11), 腺嘌呤核苷( 12) , 十六烷酸单甘油酯( 13), 十六烷酸 ( 14) 化合物 5, 7, 11~ 14, 6 [] 蒙古黄芪; 化学成分;黄酮; 皂苷 Chem ical constituents ofA strag a lus m em branaceus var. m ongho licus W EN Y uhan, * HENG L iang, ZHENG D an, HUANG X ueshi, HAN L i ( Schoo lof Pharm aceutical Sciences, hinaM edicalUniver sity, Shenyang 110001, hina) [ Abstract] Objective To study the chem ical constituents ofAstragalus membranaceu s var.mongholicu s. M ethods ompoundsw ere isolated by various chromatographic techniques and their structuresw ere elucidated on the basis of spectral analysis. Results Fourteen compoundsw ere identified as( 6aR, 11R )9, 10dmi ethoxypterocarpan3 ODglucoside( 1), ( 3R )2 hydroxy3 , 4 dmi ethoxyisoflavan7ODglucoside ( 2) , 5 hydroxy3 m ethoxy isoflavone7ODglucoside( 3) , formononetin7ODglucoside( 4) , ( 6aR, 11R )3hydroxy9, 10dmi ethoxy ptero carpan( 5), ( 3R )7, 2 dihydroxy3 , 4 dmi ethoxyisoflavan ( 6), 5 , 7dihydroxy3 m ethoxyisoflavone( 7), form onon etin( 8) , astragaloside IV( 9) , astragaloside II( 10), sucrose( 11), adenine riboside( 12), monopalm itin ( 13) , palm itic acid( 14) . Conclusion ompounds5, 7, 1114 w ere isolated from Astragalu s genus for the first tmi e, and 6 w as ob tained from this plant for the f irst tmi e. K e words:Astragalusmembranaceus var.mo