《2016 T Ley TCGA - nejmoa1301689》.pdfVIP

The new england journal of medicine established in 1812 may 30, 2013 vol. 368 no. 22 Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia The Cancer Genome Atlas Research Network A bs tr ac t Background Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) The authors (members of the Cancer Ge- are undefined. The relationships between patterns of mutations and epigenetic nome Atlas Research Network) are listed in the Appendix. Address reprint requests phenotypes are not yet clear. to Dr. Timothy J. Ley at Washington Uni- versity School of Medicine, Division of Methods Oncology, Stem Cell Biology Section, Campus Box 8007, 660 S. Euclid Ave., St. We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, Louis, MO 63110, or at timley@wustl. using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 edu. cases), along with RNA and microRNA sequencing and DNA-methylation analysis. This article was published on May 1, 2013, and updated on June 13, 2013, at NEJM.org. Results