Global Sensitivity Analysis Challenges in Biological Systems Modeling文献.pdfVIP

7168 Ind. Eng. Chem. Res. 2009, 48, 7168–7180 Global Sensitivity Analysis Challenges in Biological Systems Modeling A. Kiparissides, S. S. Kucherenko, A. Mantalaris,* and E. N. Pistikopoulos Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, U.K. Mammalian cell culture systems produce high-value biologics, such as monoclonal antibodies, which are