《Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis》.pdf
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《Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis》.pdf
Q J Med 2007; 100:193–201
doi:10.1093/qjmed/hcm015
Review
Anti-CCP antibody testing as a diagnostic and prognostic
tool in rheumatoid arthritis
T.B. NIEWOLD, M.J. HARRISON and S.A. PAGET
From the Department of Rheumatology, Hospital for Special Surgery, New York, NY, USA
Summary
Rheumatoid arthritis is both common and chronic, disease process, and ability to identify patients who
with significant consequences for multiple organ are likely to have severe disease and irreversible
systems. Better understanding of its pathophysiology damage. However, its sensitivity is low, and a
has led to the development of targeted therapies that negative result does not exclude disease. Anti-CCP
have dramatically improved outcomes. The key to antibodies have not been found at a significant
therapeutic success lies in identifying individuals frequency in other diseases to date, and are more
who will have severe destructive disease as early as specific than rheumatoid factor for detecting rheu-
possible, so that effective treatment can be initiated matoid arthritis. We discuss anti-CCP antibody
before irreversible damage occurs. Anti-cyclic testing in rheumatoid arthritis, with an emphasis
citrullinated peptide (anti-CCP) antibody testing is on diagnostic performance, prognostic capability,
particularly useful in the diagnosis of rheumatoid and relevance to pathogenesis and new treatment
arthritis, with high specificity, presence early in the paradigms in rheumatoid arthritis.
Introduction
Rheumatoid arthritis (RA) is a severe, progres- complicated by moderate sensitivity and specificity,
sive, systemic inflammatory disease of unknown and high rates of positivity in other chronic
aetiology. The morbidity and
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