Survivin蛋白、CDX2在结直肠癌及癌前病变中的表达和意义卒.pdfVIP

现代消化及介入诊疗 2015 年 第20 卷 第4 期 Modern Digestion Intervention 2015, Vol.20, No.4 -325 - 窑论 著窑 Survivin蛋白尧CDX2在结直肠癌及癌前病变 中的表达和意义 姚凡保 付 汐 邝倩仪 马海生 揖摘要铱目的 探讨 Survivin蛋白尧CDX2在结直肠癌及癌前病变中的表达袁为结直肠癌的早期诊断尧 基因靶点治疗尧评估预后尧判断复发提供新的标记物遥方法 收集结直肠癌尧腺瘤伴高级别上皮内瘤变尧腺 瘤伴低级别上皮内瘤变及正常对照组各 30例袁应用免疫组化方法分别检测各组中 Survivin蛋白尧CDX2 的表达情况遥结果 Survivin蛋白表达在腺癌组尧高级别上皮内瘤变组尧低级别上皮内瘤变组及正常组各 组间均有明显差异渊P约0.01冤曰CDX2表达在腺癌组与低级别瘤变组尧正常组之间袁高级别上皮内瘤变组 与低级别上皮内瘤变组尧正常组之间袁低级别上皮内瘤变组与正常组之间均有显著差异渊P约0.01冤袁而腺 癌组与高级别组之间无明显差异渊P跃0.05冤遥Survivin与 CDX2的表达呈高度密切负相关渊r越-0.64袁P约 0.01冤遥结论 Survivin蛋白尧CDX2是结直肠癌发生发展的重要生物学标记物袁两者有密切相关性袁联合检 测可为结直肠癌早期诊断尧基因靶点治疗尧评估预后尧判断复发提供新的手段遥 揖关键词铱Survivin曰CDX2曰结直肠癌曰上皮内瘤变 ExpressionandsignificanceofSurvivinprotein,CDX2incolorectalcancerandprecancerousdiseases YAOFan-bao,FUXi,KUANGQian-yi,MAHai-sheng.FoshanSanshuiDistrictPeople忆sHospitalofthe digestivedepartment528100 揖Abstract铱 ObjectiveToinvestigatetheexpressionofSurvivinandCDX2incolorectalcancer,andto discusstheroleofbiologicalmarkersinearlydetectionofcolorectalcancer,geneticallytargetedtreatment,as原 sessmentofprognosis,diagnosisofrecurrent.MethodsCollectingthecolorectalcancer,adenomawithhigh- gradeintraepithelialneoplasia,adenomawithlowgradeintraepithelialneoplasiaandnormalcontrolgroupwith 30casesineachgroup,thendetectingtheexpressionofSurvivinandCDX2withimmunohistochemistry.Re原 sultsTheexpressionofSurvivinproteininthecancergroup,highgradeintraepithelialneoplasiagroup,low gradeintraepithelialneoplasiagroup,normalgroupweresignificantlydifferent(P0.01);theexpressionof CDX2inadenocarcinomagroupshowedsignificantdifferencewithlowgradeneoplasiagroupandnormal group,highgradeintraepithelialneoplasiagroupshowedsignificantdifferencewithlowgradeintraepithelial neoplasiagroupandnormalgroup,lowgradeintraepithelialneoplasiawassignificantlydifferentwithnormal group(P0.01),whilenosignificantdifferencebetweentheadenocarcinomagroupandhig