自噬与心肌缺血再灌注损伤刘友斌.pdfVIP

# 2478# C inese Journal of Pat op ysiology 2009, 25( 12): 2478- 2482 [ ] 1000- 4718( 2009) 12- 2478- 05 * / 刘友斌, 杨树森, 樊 瑛, 甘润韬 ( , 150001) Autophagy andmyocardial ischemia/reperfusion injury LIU You- bin, YANG S u- sen, FAN Y ing, GAN Run- tao (D ep artm ent of Card iology, The F irstAff iliated H osp ital of H aerbin M ed ical Un iv ers ity, H aerbin 150001, Ch ina. E - ma il a in i2002yx@ 163. com ) = ABSTRACT Au top agy is a lysosom e- dependent degradative pat way w ic is c aracterized by cytop lasm ic vacuolization. How ever, it is not just a smi ple degradative pat w ay. Researc s ow s t at autop agy is related to m any dis- eases, suc as neurodegenerative d isease, malignant tum or, ageing, pat ogen icm icroorgan ism infection, m yocardial isc e- m ia/ reperfusion injury and so on. Au top agy exactly exists in m yocardial isc em ia/ reperfusion injury, and it becom es a new researc otspot. T is review w ill focus on t e occurrence and development of autop agy and its role, signal transduc- tion and researc status in m yocard ial isc em ia/reperfusion injury. [ ] ; ; ; [KEY ORDS] Autop agocytosis; M yocardial isc em ia; Reperfusion injury; S ignal transduction [ ] R363 [ ] A 1962 1 lig t c ain 3, MAP 1- LC3) 2 , : A tg12- LC3 [ 1] , , A tg12- ( preautop agosom e), LC3 ( autop agosome) , A tg12E1A tg7, E2 , A tg10, A tg5, ( au- /, top agosomalprecursor) LC3( ProLC3), / LC3- I, , LC3 - I A tg7 1 ,,, , 2 E2A tg3,