自噬现象综述.pdfVIP

REVIEW Focus on AuTo PHAGY Eaten alive: a history of macroautophagy Zhifen Yang and Daniel J. Klionsky Macroautophagy (hereafter autophagy), or ‘self-eating’, is a conserved cellular pathway that controls protein and organelle degradation, and has essential roles in survival, development and homeostasis. Autophagy is also integral to human health and is involved in physiology, development, lifespan and a wide range of diseases, including cancer, neu