中药指纹图谱技术进展和未来发展方向展望_李强.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第44 卷 第22 期 2013 年11 月 ·3095 · ·专 论 · 中药指纹图谱技术进展及未来发展方向展望 李 强，杜思邈，张忠亮，吕春明，周永全，赵 燕，张 宁* 上海中医药大学 科技实验中心，上海 201203 摘 要：中药指纹图谱在现代及未来的中药质量控制中都占有很重要的地位，其可分析中药中有效成分和无效成分的种类和 含量分布的信息，符合中医中药整体性和模糊性的特点。随着越来越多的技术不断被应用于中药指纹图谱的研究，中药指纹 图谱必在中药质量控制、中药药效成分研究、中药作用机制研究等多方面发挥更加重要的作用。总结了近年来中药指纹图谱 研究技术和分析方法的进展，并就其未来发展方向进行探析。 关键词：中药；质量控制；指纹图谱；药效成分；作用机制 中图分类号：R284.1 文献标志码：A 文章编号：0253 - 2670(2013)22 - 3095 - 10 DOI: 10.7501/j.issn.0253-2670.2013.22.001 Progress in fingerprint technology on Chinese materia medica and prospect of its future development LI Qiang, DU Si-miao, ZHANG Zhong-liang, LV Chun-ming, ZHOU Yong-quan, ZHAO Yan, ZHANG Ning Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Abstract: Fingerprint of Chinese materia medica (CMM), which could be used to comprehensively analyze the information of the type and content distribution of the effective and ineffective components in CMM, is in line with the integral and fuzzy characteristics of CMM and has held its own important space in modern and future CMM quality control. As more and more technologies have been applied to the fingerprint research of CMM, it is sure to play a much more important role in many aspects, such as the quality control of CMM, the researches of efficient components, and the mechanism in CMM, and so on. This paper generalizes the research in progresses in research and analytic methods on CMM fingerprint technology, and the prospect of the future development in the fingerprint is discussed. Key words: Chinese materia medica; quality control; fingerprint; efficacious constituents; mechanism of action 随着中药在国际上的广泛应用，其有效性、安 特征、颜色反应、浸出物等）组成的。由药材中单 全性问题引起了广泛关注。建