外周T细胞淋巴瘤继发弥漫大B细胞淋巴瘤一例并文献复习.pdfVIP

鱼堕堑：鲞里擅垫!!堡!旦笙丝鲞星!塑!坐望趔堕!竺!!竺堕垫垃竺21塑!!墅罂壁!Q!!!!!!：丝!堕!：! ·457· ·论著· 外周T细胞淋巴瘤继发弥漫大B细胞 淋巴瘤一例并文献复习 吕瑞邱录贵徐燕李健李增军 【摘要】 目的探讨外周T细胞淋巴瘤(PTCL)继发弥漫大B细胞淋巴瘤(DLBCL)的诊治方法。 方法报道1例PTCL继发DLBCL病例的诊治经过，分析该例患者的临床特点、治疗反应，复习文献探 讨该类疾病的机制及预后。结果患者诊断PTCL非特指型(PTCL—NOS)明确，治疗后出现以EB病毒 (EBV)阴性DLBCL为表现的第He瘤，其临床特点及发病间隔与之前国外报道类似，可能涉及肿瘤细 胞、微环境及治疗等多方面因素。该例患者初步治疗有效，有待进一步随访观察。结论PTCL—NOS继发 EBV阴性DLBCL非常罕见，发病机制和治疗效果有待进一步探索。 【关键词】外周T细胞淋巴瘤，非特指型；淋巴瘤，大细胞，弥漫型；EB病毒 diffuse B-cell after T-cell nototherwise Sequentiallarge lymphomaperipherallymphoma specified：a case andreviewofliterature Jian，Li report LyuRui，QiuLugui，XuYon，Li Zen百un．Instituteof D如e∞e ChineseA Medical UnionMedical HematologyBloodHospital, cademyof SciencesPeking 30002 D，China College，Tianjin author：Li CorrespondingZen百un，Emaihzen百unli@163．COrn To the andtreatmentof diffuseB-cell 【Abstract】Objectiveinvestigatediagnosis sequentiallarge T—cell Acasewith DLBCLafter lymphoma(DLBCL)afterperipherallymphoma(PTCL)．Methodssequential and ofthiscasewere literature PTCLwas thecharacteristics analyzed．Theprevious reported，and responses wasreviewedinorderto themechanismand ofsuch ofdisease．ResllltsThis explain prognosistype patient a was asPTCLnototherwise after oftreatment，DLBCL diagnosed specified(PTCL—NOS)definitely，butperiod in was asasecondtumor．Thecharacteristicsandonsetintervalwere similartothosedescribed developed just the whichthemechanismswerem