肉瘤中+FGFR+信号通路研究进展.pdfVIP

. 720 . 中国骨与关节杂志 2015 年 9 月第 4 卷第 9 期 Chinese Journal of Bone and Joint, September 2015, Vol 4, No.9 . 综述 Review . 肉瘤中 FGFR 信号通路研究进展 周文雅　王国文　杨蕴　杨吉龙 DOI: 10.3969/j.issn.2095-252X.2015.09.015　　中图分类号：R738 基金项目：国家自然科学基金 (81402215 ) 作者单位：300060　天津医科大学附属肿瘤医院骨与软组织肿瘤科；国家肿瘤临床研究中心；天津市肿瘤防治重点 　　　　　实验室 通信作者：杨吉龙，Email: yangjilong@ Update of fibroblast growth factor receptor signaling pathway in sarcoma ZHOU Wen-ya, WANG Guo-wen, YANG Yun, YANG Ji-long. National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute Hospital, Tianjin, 30060, PRC Corresponding author: YANG Ji-long, Email: yangjilong@ Abstract Sarcomas are derived from mesenchymal tissues, with poor outcomes of traditional treatment such 【 】 as surgery, chemotherapy, and radiotherapy. Hence, new treatment methods such like target therapy in human cancer are very necessary. Fibroblast growth factor receptor ( FGFR ) signaling pathway plays a ubiquitous role in a variety of biological processes including regulating normal cell growth, proliferation, differentiation, and angiogenesis, but has also associated with a variety of dysplasia syndromes and cancers. The therapies and related drugs which target at FGFR signaling pathway have made great progress in the field of tumors. An overview of the role of FGF / FGFR pathway signal and their inhibitors in sarcoma which might be new targets for the treatment of sarcomas according to the recent research will be presented. Key words Sarcoma; Fibroblast growth factors; Fibroblast growth factor receptors; Signal transduction; 【 】 Molecular targeted therapy 【关键词】　肉瘤；成纤维细胞生长因子；成纤维细胞生长因子受体；信号传导；分子靶向治疗 肉瘤是来自于神经、肌肉、脂肪和骨骼等间叶组织 一、FGFs 的少见的恶性肿瘤，它可以发生于全身各处，尤其好发于 FGFs 几乎在所有组织中均有表达，可通过刺激多 肢体深部组织