Association+between+Prenatal+Environmental+Factors+and+Child+Autism-A+Case+Control+Study+in+Tianjin,+China.pdfVIP

642 Biomed Environ Sci, 2015; 28(9): 642-650 Original Article Association between Prenatal Environmental Factors and Child Autism: A Case Control Study in Tianjin, China* 1 1 2 1 1 1 1,# GAO Lei , XI Qian Qian , WU Jun , HAN Yu , DAI Wei , SU Yuan Yuan , and ZHANG Xin 1. Dept. Maternal, Child Adolescence Heal th of School of Public Health, Tianjin Medical University, Tianjin 300070, China; 2. Program in Public Health and department of Epidemiology, University of California, Irvine, USA Abstract Objective To investigate the association between autism and prenatal environmental risk factors. Methods A case-control study was conducted among 193 children with autism from the special educational schools and 733 typical development controls matched by age and gender by using questionnaire in Tianjin from 2007 to 2012. Statistical analysis included quick unbiased efficient statistical tree (QUEST) and logistic regression in SPSS 20.0. Results There were four predictors by QUEST and the logistic regression analysis, maternal air conditioner use during pregnancy (OR=0.316, 95% CI: 0.215-0.463) was the single first-level node 2 (χ =50.994, P=0.000); newborn complications (OR=4.277, 95% CI: 2.314-7.908) and paternal consumption of freshwater fish (OR=0.383, 95% CI: 0.256-0.573) were second-layer predictors 2 2 (χ =45.248, P=0.000; χ =24.212, P=0.000); and maternal depression (OR=4.822, 95% CI: 3.047-7.631)