Enhancing+endogenous+stem+cells+in+the+newbornvia+delayed+umbilical+cord+clamping.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 INVITED REVIEW Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping Christopher Lawton, Sandra Acosta, Nate Watson, Chiara Gonzales-Portillo, Theo Diamandis, Naoki Tajiri, Yuji Kaneko, Paul R. Sanberg, * Cesar V. Borlongan Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA Abstract *Correspondence to: There is currently no consensus among clinicians and scientists over the appropriate or optimal Cesar V. Borlongan, Ph.D., timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cborlong@. cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and orcid: decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood con- 0000-0002-2966-9782 tains significant amounts of stem and progenitor cells and is currently used in the treatment of (Cesar V. Borlongan) several life-threatening diseases. We propose that delayed cord clamping be encouraged as it en- hances blood flow from the placenta to the neonate, which is accompanied by an increase supply doi: 10.4103/1673-5374.165218 of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase / blood volume, altogether reducing the infant’s susceptibility to both neonatal an