Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus》.pdfVIP

Atherosclerosis 157 (2001) 131–135 /locate/atherosclerosis Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus R. Fre´nais a, K. Ouguerram a, C. Maugeais a, P. Mahot b, B. Charbonnel b, T. Magot a, M. Krempf a,b,* a Centre de Recherche en Nutrition Humaine, Groupe Me´tabolisme, INSERM U539, Hoˆtel Dieu, Nantes, France b Clinique d’Endocrinologie, Maladies Me´taboliques et Nutrition, Hoˆtel Dieu, Nantes, France Received 25 April 2000; received in revised form 22 September 2000; accepted 19 October 2000 Abstract The effect of a dietary fish oil supplementation on metabolism of HDL was studied in type II diabetes mellitus. Endogenous labeling of HDL-apo AI was performed using a 14 h primed infusion of D3-leucine in five diabetic patients before and 2 months after treatment with maxEPA® . Isotopic enrichment curves were analyzed using a monoexponential function. After treatment, plasma cholesterol level remained unchanged (205.4 41.9 vs. 206.8 30.7 mg/dl, NS), whereas plasma triglycerides were decreased (155.4 67.9 vs. 202.6 32.2 mg/dl, P =0.06). Plasma apo AI was similar under maxEPA® (116.0 25.6 vs. 111.8 25.4 mg/dl, NS), and HDL-cholesterol and HDL-triglycerides were also not markedly changed (30.2 10.0 vs. 27.1 10 mg/dl, and 15.3 9.8 vs. 19.2 10.4 mg/dl, NS). HDL-apo AI fractional catabolic rate (FCR) and absolute production rate (APR) were significantly decreased after treatment with maxEPA® (0.27 0.09 vs. 0.37 0