GABA-ergic interneurons involved in transcallosal inhibition of the visual cortices in vivo in mice》.pdfVIP

Physiology Behavior 151 (2015) 502–508 Contents lists available at ScienceDirect Physiology Behavior journal homepage: /locate/phb GABA-ergic interneurons involved in transcallosal inhibition of the visual cortices in vivo in mice Xiao-fei He a,1, Yue Lan b,1, Qun Zhang a, Feng-yin Liang c, Chuan-ming Luo c, Guang-qing Xu a,⁎, Zhong Pei c a Department of Rehabilitation Medicine, The First Affi liated Hospital, Sun Yat-sen University, Guangzhou, China b Department of Rehabilitation Medicine, Guangzhou First Peoples Hospital, Guangzhou Medical University, Guangzhou, China c Department of Neurology, The First Affi liated Hospital, Sun Yat-sen University, Guangzhou, China H I G H L I G H T S • We examined the mechanism of interhemispheric inhibition of visual cortices. • We used in vivo two-photon Ca2+ imaging to detect the neuronal activities. • We used callosotomy to explore the transcallosal inhibition of visual cortices. • The long-range GABAergic circuit may be directly involved in transcallosal inhibition. a r t i c l e i n f o a b s t r a c t Article history: In the current study we investigated the role of the corpus callosum, particularly the gamma-aminobutyric acid- Received 15 May 2015 ergic (GABAergic) projection neurons involved in interhemispheric inhibition (IHI). In order to explore IHI in pri- Received in revised form 17 August 2015 mary visual cortices, we adopted a protocol whereby we performed a direct current lesion of the unilateral pri- Accepted 18 August 2015