Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation》.pdfVIP

Molecular Cell Article Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation Ge Zhou,1,* Jiping Wang,1 Mei Zhao,1 Tong-Xin Xie,1 Noriaki Tanaka,1 Daisuke Sano,1 Ameeta A. Patel,1 Alexandra M. Ward,1 Vlad C. Sandulache,1 Samar A. Jasser,1 Heath D. Skinner,1 Alison Lea Fitzgerald,1 Abdullah A. Osman,1 Yongkun Wei,2 Xuefeng Xia,5,6 Zhou Songyang,7,8 Gordon B. Mills,3 Mien-Chie Hung,2,9 Carlos Caulin,1,4 Jiyong Liang,3 and Jeffrey N. Myers1,5,* 1Department of Head and Neck Surgery 2Department of Molecular and Cellular Oncology 3Department of Systems Biology 4Department of Genetics 5Department of Cancer Biology The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 6Center for Diabetes Research, Methodist Hospital Research Institute, Houston, TX 77030, USA 7Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA 8School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China 9Graduated Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan *Correspondence: gzhou@ (G.Z.), jmyers@ (J.N.M.) /10.1016/j.molcel.2014.04.024 SUMMARY mechanisms involved in mutp53 gain of function (GOF) remain relatively poorly understood (Oren and Rotter, 2010). Many mutant p53 proteins (mutp53s) exert onco- Metabolic alterations, particularly the metabolic reprogram- genic gain-of-function (GOF) properties, but the ming to aerobic glycolysis (i.